By P. C. Doherty (auth.), Francis V. Chisari M.D., Michael B. A. Oldstone M.D. (eds.)
Most ailments are multifactoral. Transgenic expertise allows gene(s) of curiosity to be expressed in a small manipulatable laboratory animal version. via this technique, murine versions of human infections might be constructed and studied; results of cytokines in vivo, focally expressed in targeted cells could be proven and manipulated, and quite a few autoimmune problems, mimicking human illness might be built. during this quantity, those ways for learn of human immunodeficiency virus, hepatitis virus, viruses inflicting tumors and protracted degenerative issues are defined. additionally incorporated are chapters of transgenic versions of autoimmune problems like diabetes, systemic lupus and ankylosing spondylitis.
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Extra info for Transgenic Models of Human Viral and Immunological Disease
In H-2u mice, the response to the MBP(1-20) epitope was comparable in wild-type and shiverer mice; however, only the shiverer mice responded well to the MBP(121-141) epitope . Thus, tolerance to MBP in H-2u mice was observed for some epitopes of MBP but not for others. Epitope-specific tolerance has previously been demonstrated in the murine response to hen egg lysozyme (HEL) (GAMMON and SERCARZ 1989). After intravenous injection of tolerogenic doses of HEL, mice could not respond to dominant HEL epitopes, but could respond to minor HEL determinants.
1 ~MMBP 1 10 Fig. 1. Myelin basic protein (MBP)-deficient shiverer mice are hyper-responsive to MBP. H-2d or H-2u, wildtype or shiverer mice were immunized with 50 ~g of mouse MBP emulsified in complete Freund's adjuvant. Draining lymph node cells were collected 10 days later and cultured with various concentrations of mouse MBP. A total of 3 x 105 lymph node cells were cultured in triplicate wells of 96-well microtiter plates. The plates were incubated at 37°C for 5 days. LCi of [3HI thymidine was added.
In: Morell P (ed) Myelin. Plenum, New York, pp 197-224 Linthicum DS (1982) Development of acute autoimmune encephalomyelitis in mice: factors regulating the effector phase of the disease. Immunobiology 162: 211-220 Miller A. Lider 0, Roberts AB, Sporn MB, Weiner HL (1992) Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 89: 421-425 Mokhtarian F, McFarlin DE, Raine CS (1984) Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice.
Transgenic Models of Human Viral and Immunological Disease by P. C. Doherty (auth.), Francis V. Chisari M.D., Michael B. A. Oldstone M.D. (eds.)