New PDF release: Transgenic Models of Human Viral and Immunological Disease

By P. C. Doherty (auth.), Francis V. Chisari M.D., Michael B. A. Oldstone M.D. (eds.)

ISBN-10: 3642852084

ISBN-13: 9783642852084

ISBN-10: 3642852106

ISBN-13: 9783642852107

Most ailments are multifactoral. Transgenic expertise allows gene(s) of curiosity to be expressed in a small manipulatable laboratory animal version. via this technique, murine versions of human infections might be constructed and studied; results of cytokines in vivo, focally expressed in targeted cells could be proven and manipulated, and quite a few autoimmune problems, mimicking human illness might be built. during this quantity, those ways for learn of human immunodeficiency virus, hepatitis virus, viruses inflicting tumors and protracted degenerative issues are defined. additionally incorporated are chapters of transgenic versions of autoimmune problems like diabetes, systemic lupus and ankylosing spondylitis.

Show description

Read or Download Transgenic Models of Human Viral and Immunological Disease PDF

Similar viral books

Viral Meningitis - A Medical Dictionary, Bibliography, and - download pdf or read online

In March 2001, the nationwide Institutes of healthiness issued the subsequent caution: "The variety of sites supplying health-related assets grows on a daily basis. Many websites supply priceless info, whereas others can have info that's unreliable or deceptive. " additionally, as a result of speedy raise in Internet-based details, many hours should be wasted looking out, settling on, and printing.

Read e-book online Pubic Lice: A Medical Dictionary, Bibliography, And PDF

In March 2001, the nationwide Institutes of overall healthiness issued the subsequent caution: "The variety of sites supplying health-related assets grows on a daily basis. Many websites supply worthy details, whereas others could have details that's unreliable or deceptive. " moreover, due to the fast bring up in Internet-based details, many hours may be wasted looking, deciding on, and printing.

Living Together: The Biology of Animal Parasitism by William Trager (auth.) PDF

William Trager has been an avid pupil of parasites for over 50 years on the Rockefeller college. round the flip of this century, parasitology loved a definite style, encouraged through colonial duties of the technically advert­ vanced international locations, and through the intriguing etiological and healing discoveries of Ross, Manson, Ehrlich, and others.

Get Assisted Reproductive Technologies and Infectious Diseases: PDF

This concise and sensible e-book is the 1st of its variety to ascertain using assisted reproductive applied sciences (ART) relating to blood-borne infectious illnesses: human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV). The e-book opens with a dialogue of the influence of those viruses on female and male fertility, via particular chapters of every of them, together with paintings with HIV and HCV serodiscordant (where both the male or woman is optimistic) and the detection and effect of HBV and HCV in human gametes and embryos.

Extra info for Transgenic Models of Human Viral and Immunological Disease

Sample text

In H-2u mice, the response to the MBP(1-20) epitope was comparable in wild-type and shiverer mice; however, only the shiverer mice responded well to the MBP(121-141) epitope . Thus, tolerance to MBP in H-2u mice was observed for some epitopes of MBP but not for others. Epitope-specific tolerance has previously been demonstrated in the murine response to hen egg lysozyme (HEL) (GAMMON and SERCARZ 1989). After intravenous injection of tolerogenic doses of HEL, mice could not respond to dominant HEL epitopes, but could respond to minor HEL determinants.

1 ~MMBP 1 10 Fig. 1. Myelin basic protein (MBP)-deficient shiverer mice are hyper-responsive to MBP. H-2d or H-2u, wildtype or shiverer mice were immunized with 50 ~g of mouse MBP emulsified in complete Freund's adjuvant. Draining lymph node cells were collected 10 days later and cultured with various concentrations of mouse MBP. A total of 3 x 105 lymph node cells were cultured in triplicate wells of 96-well microtiter plates. The plates were incubated at 37°C for 5 days. LCi of [3HI thymidine was added.

In: Morell P (ed) Myelin. Plenum, New York, pp 197-224 Linthicum DS (1982) Development of acute autoimmune encephalomyelitis in mice: factors regulating the effector phase of the disease. Immunobiology 162: 211-220 Miller A. Lider 0, Roberts AB, Sporn MB, Weiner HL (1992) Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 89: 421-425 Mokhtarian F, McFarlin DE, Raine CS (1984) Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice.

Download PDF sample

Transgenic Models of Human Viral and Immunological Disease by P. C. Doherty (auth.), Francis V. Chisari M.D., Michael B. A. Oldstone M.D. (eds.)


by Ronald
4.5

Rated 4.61 of 5 – based on 48 votes