Get Analysis of Marine Samples in Search of Bioactive Compounds PDF

By Teresa Rocha-Santos, Armando C. Duarte

ISBN-10: 0444633596

ISBN-13: 9780444633590

ISBN-10: 0444633812

ISBN-13: 9780444633811

Seas and oceans supply a variety of temperature, strain, gentle and chemical conditions thus permitting a large range of marine organisms from shallow coastal waters to the deep ocean. those assets can be utilized to procure new items and advance providers, and in flip support to provide solutions to the demanding situations that have an effect on our planet, together with delivering a sustainable offer of nutrients and effort, new commercial fabrics and tactics, new bioactive compounds, and new health and wellbeing remedies. Marine compounds were pointed out as having antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral actions. the key resources of those bioactive compounds are marine sponges, coelenterates, and microorganisms, by way of algae, echinoderms, tunicates, molluscs, and bryozoans.

The discovery of bioactive compounds from marine samples is a sizzling subject contemplating the present need for sustainable use of marine assets. This booklet is a finished evaluation of the analytical techniques employed within the discovery and characterization of bioactive compounds remoted from (all attainable) marine samples and offers destiny views of analytical methodologies. This assessment comprises an review of the sampling and guidance of extracts, the separation and isolation of bioactive compounds, their structural characterization and the appliance of bioassays within the discovery of bioactive compounds.

  • Comprehensive insurance of analytical suggestions and applications
  • Clear diagrams to properly help vital topics
  • Real examples of functions of analytical concepts within the look for new bioactive compounds

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Extra info for Analysis of Marine Samples in Search of Bioactive Compounds

Sample text

B 803 (2004) 41–53. G. W. J. H. E. Lill, S. N. R. Duckworth, J. Biotechnol. 70 (1999) 15–25. [14] K. au/theses/278). [15] A. McMinn, A. Pankowski, T. Delfatti, J. Phyc. 41 (2005) 732–741. [16] M. Synnes, Clean Techn. Environ. Policy 9 (2007) 53–59. F. S. L. R. C. Esteves, Curr. Opin. Biotechnol. 22 (2011) S80. [18] C. S. J. Y. Phang, A. Penesyan, S. Egan, P. Steinberg, S. Kjelleberg, PLoS One 3 (2008) 1–7. S. B. Glaser, C. S. Jacobs, W. D. M. J. C. E. Shuster, Trends Pharmacol. Sci. 31 (2010) 255–265.

Final purification of compounds with HPLC (C-18 column with a gradient solvent system from 20 to 100% of acetonitrile in water). [39] Gastropod Cellana radiata East Coast of South India Anticancer bioactive compound Soxhlet extraction with diethyl ether — [40] Anti-coagulant compounds: glycosaminoglycans Methanol (85%, v/v) Ion-exchange column chromatography with DEAEcellulose (eluted with distilled water and NaCl) and Amberlite IRA-900. Final purification of compounds with column chromatography with Sephadex G-100.

65. V. All rights reserved 35 36 Analysis of Marine Samples in Search of Bioactive Compounds Lyngbya majuscule with antifouling properties, such as dolastatin 16 A, hantupeptin C, majusculamide A, and isomalyngamide. In order to be available for practical applications, the bioactive compounds should be isolated from marine organisms following a procedure with several steps. First, the marine organisms are sampled from the environment and grown at the laboratory in a nutritional media. In this step, special attention should be taken since the culture conditions, such as temperature, aeration, pH of the media, incubation time, and media composition, can affect the production of the desired bioactive compound (discussed by Penesyan et al.

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Analysis of Marine Samples in Search of Bioactive Compounds by Teresa Rocha-Santos, Armando C. Duarte


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