By Philippe Jeanteur
Splicing of basic RNA transcript is a quasi-systematic step of gene expression in greater organisms. this is often the 1st ebook to focus on the clinical implications, i.e. illnesses, attributable to substitute splicing. substitute splicing not just enormously raises protein range but additionally bargains quite a few possibilities for aberrant splicing occasions with pathological effects. The booklet additionally outlines attainable objectives for treatment.
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Extra resources for Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology)
2 Low Molecular Weight Drugs It is well known that small molecules can interact with RNA, and this principle is used by several RNA-binding antibiotics, such as gentamicin, chloramphenicol, and tetracycline (Xavier et al. 2000). Therefore, several chemical screens were performed to identify small-molecular-weight molecules that interfere with splice site selection. It was found that (−)-epigallocatechin gallate (EGCG), a polyphenol and component of green tea (Anderson et al. 2003), as well as kinetin and the related benzyladenine, a plant hormone (Slaugenhaupt et al.
It will therefore be necessary to analyze data obtained with exon-specific microarrays with different software tools that use gene ontologies to detect coordinated small changes in groups of exons (Ben-Shaul et al. 2005). 6 Conclusions Misregulated alternative splicing emerges as a new cause for human diseases. Recent progress shows that misregulation of alternative splicing can be reversed. Most of the treatment paradigms are in the experimental stage. However, the growing list of drugs interfering with splice-site selection promises that some treatment options will be moved to the clinic soon.
Nucleic Acids Res 33: e47 Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, Avanzini MA, Marconi M, Badolato R, Ugazio AG, Levy Y, Catalan N, Durandy A, Tbakhi A, Notarangelo LD, Plebani A (2001) Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A 98: 12614–12619 Fischer DC, Noack K, Runnebaum IB, Watermann DO, Kieback DG, Stamm S, Stickeler E (2004) Expression of splicing factors in human ovarian cancer. Oncol Rep 11: 1085–1090 Garcia-Blanco MA, Baraniak AP, Lasda EL (2004) Alternative splicing in disease and therapy.
Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology) by Philippe Jeanteur