Download e-book for iPad: Adenosine Receptors in Neurology and Psychiatry, by Akihisa Mori

By Akihisa Mori

ISBN-10: 0128010223

ISBN-13: 9780128010228

ISBN-10: 0128013184

ISBN-13: 9780128013182

This well-established overseas sequence examines significant components of uncomplicated and medical examine inside of neuroscience, in addition to rising and promising subfields. This quantity concentrates on adenosine receptor technology, delivering insights beneficial for genuine drug discovery/development in neurology and psychiatry areas.

  • Expertise of contributors
  • Subject together with useful drug improvement from easy technology, as translational examine taste
  • Structure of contents targeting CNS parts for ailments (neurology and psychiatry)

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Extra info for Adenosine Receptors in Neurology and Psychiatry,

Sample text

2004). , 2004). , 2003). 7. , 2003). The ability of A2AR agonists to inhibit TNF-α production while increasing VEGF expression allows macrophages to switch from an inflammatory to an angiogenic phenotype. , 2005). , 2010). 8. AR control of cerebral blood flow and blood–brain barrier integrity The vasodilator adenosine has been identified as an important mediator that couples cerebral blood flow to neuronal activation (Dirnagl, Niwa, Lindauer, & Villringer, 1994). Thus, adenosine mediates glutamate-induced vasodilation in the cerebral cortex (Iliff, D’Ambrosio, Ngai, & Winn, 2003; Ohata, Cao, & Koehler, 2006).

Et al. (2013). The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure, 21, 2175–2185. , & Boison, D. (2005). Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Experimental Neurology, 193, 53–64. Halassa, M. , & Haydon, P. G. (2007). The tripartite synapse: Roles for gliotransmission in health and disease. Trends in Molecular Medicine, 13, 54–63.

N. (2006). Tumor necrosis factoralpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane. Molecular Pharmacology, 69, 1311–1319. , Klutz, A. , & Jacobson, K. A. (2008). Toward multivalent signaling across G protein-coupled receptors from poly(amidoamine) dendrimers. Bioconjugate Chemistry, 19, 406–411. King, A. , Ackley, M. , Cass, C. , Young, J. , & Baldwin, S. A. (2006). Nucleoside transporters: From scavengers to novel therapeutic targets.

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Adenosine Receptors in Neurology and Psychiatry, by Akihisa Mori

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