By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)
This booklet presents a accomplished, up to date assessment of the distribution, pharmacology and body structure of vital 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes convey a distinct pharmacology, distribution and serve as, of which the 5-HT4 receptor has been probably the most intensively studied lately, either from a uncomplicated learn perspective and as a objective for novel therapeutics.
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Extra resources for 5-HT4 Receptors in the Brain and Periphery
8 The cloned 5-HT1 receptors are: s-HT1A/9,315-HT1B>1,14,2B,37,52M 5-HT1D>u,25M 5-HT1E33,39,55 and 5-HT1p. 2'6 ' 35 The major signal transduction pathway for each subtype is the inhibition of adenylate cyclase activity. The 5-HT2 receptors include: 5-HT2A, 45 5-HT2B20 >32 and 5-HT2c. 29 The primary signal transduction pathway of each of these receptors is phosphoinositide hydrolysis. 36 The 5-HT5A and 5-HT5Breceptors are similar in pharmacological profile, but not primary structure, to some 5-HT1receptors.
References 1. 2. 3· 4· 5· 6. Dumuis A, Bouhelal R, Sebben M et al. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol Pharmacol 1988; 34:880-887. Dumuis A, Bouhelal R. Sebben Metal. A 5-HT receptor in the central nervous system positively coupled to adenylate cyclase is antagonized by ICS 205-930. Eur J Pharmacol 1988; 146:187-188. Bockaert J, Fozard JR, Dumuis A et al. The 5-HT4 receptor: a place in the sun. Trends Pharmacol Sci 1992; 13:141-145.
47· Eglen RM, Bonhaus DW, Clark RS et al. (R) and (S) RS 56532: mixed 5-HT3 and 5-HT4 receptor ligands with opposing enantiomeric selectivity. Neuropharmacol1994; 33:515-526. 48. Fontana DJ, Wong EHF, Clark R et al. Pro-cognitive effects of RS-66331, a mixed 5-HT3 receptor antagonist/s-HT4 receptor agonist. Proceedings of the Third IUPHAR Satellite Meeting on Serotonin. Chicago 1994:57:abst 1. 49. Eglen, RM, Wong EHF, Dumois et al. Central 5-HT4 receptors. Trends Pharmacol Sci 1995; 16:391-398.
5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)